Кошки

The active components of the drug R-praziquantel and milbemycin oxime provide its wide spectrum of anthelmintic action.

Milbemycin oxime is a macrocyclic lactone obtained as a result of the enzymatic activity of Streptomyces hygroscopicus var. Aureolacrimosus, is active against larvae and imago of nematodes parasitizing in the gastrointestinal tract of cats, as well as larvae of the nematode Dirofilaria immitis.

The mechanism of action of milbemycin is due to an increase in the permeability of cell membranes for chloride ions (Cl-), which leads to overpolarization of the membranes of nerve and muscle tissue cells, paralysis and death of sensitive nematodes. The maximum plasma concentration of milbemycin oxime in cats is reached within 2 hours; bioavailability is about 80%. The compound is excreted from the body mainly unchanged.

R-praziquantel (levorotatory optical isomer) is a compound of the pyrazinisoquinoline group, its mechanism of action is based on inducing the decay of tegument, persistent depolarization of helminth muscle cells, disruption of energy metabolism, which causes paralysis and death of cestodes, and promotes their excretion from the gastrointestinal tract. R-praziquantel is rapidly absorbed in the gastrointestinal tract, reaching its maximum concentration in the blood plasma after 1-3 hours, reversibly binds to serum proteins (70-80%), partially metabolized in the liver, re-excreted into the intestine, excreted from the body mainly with urine (up to 80%) within 24 hours.

The use of active R-praziquantel in the composition of the preparation (instead of the racemic mixture of optical isomers of R-praziquantel and S praziquantel) made it possible to reduce the concentration of the compound while maintaining a high level of cestodicidal activity.

Supramil tablets are classified as low-hazard substances in terms of their impact on the body (hazard class 4 according to GOST 12.1.007); in recommended doses does not have a sensitizing, embryotoxic and teratogenic effect.

The drug is toxic to bees, as well as fish and other aquatic organisms.

R-praziquantel, milbemycin.

Contraindications to the use of Supramil tablets are the increased individual sensitivity of the animal to the components of the drug, including a history, severe renal and liver dysfunction.

Emaciated animals sick with infectious diseases, cats weighing less than 0.5 kg, kittens under 6 weeks old are not subject to deworming.

Pills.

The shelf life of the medicinal product, subject to storage conditions in the manufacturer's sealed packaging, is 3 years from the date of production.

Do not use Supramil tablets beyond the expiration date.

Store Supramil tablets in the manufacturer's sealed packaging, protected from light, separate from food and feed, at a temperature not exceeding 25 C.

Keep Supramil tablets out of the reach of children.

The active components of the drug R-praziquantel and milbemycin oxime provide its wide spectrum of anthelmintic action.

Milbemycin oxime is a macrocyclic lactone obtained as a result of the enzymatic activity of Streptomyces hygroscopicus var. Aureolacrimosus, is active against larvae and imago of nematodes parasitizing in the gastrointestinal tract of cats, as well as larvae of the nematode Dirofilaria immitis.

The mechanism of action of milbemycin is due to an increase in the permeability of cell membranes for chloride ions (Cl-), which leads to overpolarization of the membranes of nerve and muscle tissue cells, paralysis and death of sensitive nematodes. The maximum plasma concentration of milbemycin oxime in cats is reached within 2 hours; bioavailability is about 80%. The compound is excreted from the body mainly unchanged.

R-praziquantel (levorotatory optical isomer) is a compound of the pyrazinisoquinoline group, its mechanism of action is based on inducing the decay of tegument, persistent depolarization of helminth muscle cells, disruption of energy metabolism, which causes paralysis and death of cestodes, and promotes their excretion from the gastrointestinal tract. R-praziquantel is rapidly absorbed in the gastrointestinal tract, reaching its maximum concentration in the blood plasma after 1-3 hours, reversibly binds to serum proteins (70-80%), partially metabolized in the liver, re-excreted into the intestine, excreted from the body mainly with urine (up to 80%) within 24 hours.

The use of active R-praziquantel in the composition of the preparation (instead of the racemic mixture of optical isomers of R-praziquantel and S praziquantel) made it possible to reduce the concentration of the compound while maintaining a high level of cestodicidal activity.

Supramil tablets are classified as low-hazard substances in terms of their impact on the body (hazard class 4 according to GOST 12.1.007); in recommended doses does not have a sensitizing, embryotoxic and teratogenic effect.

The drug is toxic to bees, as well as fish and other aquatic organisms.

R-praziquantel, milbemycin.

Contraindications to the use of Supramil tablets are the increased individual sensitivity of the animal to the components of the drug, including a history, severe renal and liver dysfunction.

Pills.

The shelf life of the medicinal product, subject to storage conditions in the manufacturer's sealed packaging, is 3 years from the date of production.

Do not use Supramil tablets beyond the expiration date.

Store Supramil tablets in the manufacturer's sealed packaging, protected from light, separate from food and feed, at a temperature not exceeding 25 C.

Keep Supramil tablets out of the reach of children.

Succinate, a triazolopyridine derivative, which is part of the drug trazodone, is an antagonist of alpha1-adenoreceptors, having sedative and anxiolytic effects, reduces the severity or suppresses the manifestation of fear, anxiety, somatic symptoms of anxiety: heart palpitations, salivation, excessive, locomotor activity, vocalization , destructive behavior, has a calming effect, reduces tension.

The mechanism of action of trazodone succinate is associated with its high affinity for subtypes A and C of 5-HT serotonin receptors, with which it enters into antagonistic or agonistic interactions, depending on the subtype, as well as with a specific ability to induce inhibition of serotonin reuptake.

Absorption of trazodone from the gastrointestinal tract after oral administration is high. Taking the drug during or immediately after feeding slows down the absorption rate of trazodone, reduces its concentration in blood plasma and prolongs the time to reach the maximum concentration. Trazodone penetrates the histohematogenous barriers, as well as into tissues and fluids (bile, saliva, milk), is metabolized in the liver to form metabolites, including the active metabolite, m-chlorophenylpiperazine. It is excreted from the body mainly in the form of inactive metabolites, mainly in the urine (about 75%) and partially in the bile.

In rare cases, when the drug is taken for the first time, the animal may experience drowsiness and impaired coordination of movements, which spontaneously pass and do not require the use of drugs. With repeated use, these side effects are not observed.

Trazodone succinate.

Contraindications for use are: increased individual sensitivity of the animal to the components of the drug, including a history, impaired liver and kidney function, diseases of the cardiovascular system and epilepsy.

Do not use the drug in females during pregnancy and breastfeeding, as well as in newborn kittens.

Pills.

The shelf life of the medicinal product, subject to storage conditions in the manufacturer's sealed packaging, is 3 years from the date of production.

Express Uspokoin tablets should not be used after the expiration date.

Store Uspokoin Express tablets in the manufacturer's closed packaging, protected from light, separate from food and feed, at a temperature not exceeding 25 ° C.

Express Uspokoin tablets should be kept out of the reach of children.

Succinate, a triazolopyridine derivative, which is part of the drug trazodone, is an antagonist of alpha1-adenoreceptors, having sedative and anxiolytic effects, reduces the severity or suppresses the manifestation of fear, anxiety, somatic symptoms of anxiety: heart palpitations, salivation, excessive, locomotor activity, vocalization , destructive behavior, has a calming effect, reduces tension.

The mechanism of action of trazodone succinate is associated with its high affinity for subtypes A and C of 5-HT serotonin receptors, with which it enters into antagonistic or agonistic interactions, depending on the subtype, as well as with a specific ability to induce inhibition of serotonin reuptake.

Absorption of trazodone from the gastrointestinal tract after oral administration is high. Taking the drug during or immediately after feeding slows down the absorption rate of trazodone, reduces its concentration in blood plasma and prolongs the time to reach the maximum concentration. Trazodone penetrates the histohematogenous barriers, as well as into tissues and fluids (bile, saliva, milk), is metabolized in the liver to form metabolites, including the active metabolite, m-chlorophenylpiperazine. It is excreted from the body mainly in the form of inactive metabolites, mainly in the urine (about 75%) and partially in the bile.

In rare cases, when the drug is taken for the first time, the animal may experience drowsiness and impaired coordination of movements, which spontaneously pass and do not require the use of drugs. With repeated use, these side effects are not observed.

Trazodone succinate.

Contraindications for use are: increased individual sensitivity of the animal to the components of the drug, including a history, impaired liver and kidney function, diseases of the cardiovascular system and epilepsy.

Do not use the drug in females during pregnancy and breastfeeding, as well as in newborn kittens.

Pills.

The shelf life of the medicinal product, subject to storage conditions in the manufacturer's sealed packaging, is 3 years from the date of production.

Express Uspokoin tablets should not be used after the expiration date.

Store Uspokoin Express tablets in the manufacturer's closed packaging, protected from light, separate from food and feed, at a temperature not exceeding 25 ° C.

Express Uspokoin tablets should be kept out of the reach of children.