Supramil for puppies and dogs weighing up to 20 kg
A superpill for a superpet.
Description and action
Supramil is a product with incredible eatability for the gentle protection of puppies and dogs from helminths. It is designed for the treatment and prevention of helminthiasis (round and tapeworms) in animals, as well as for the prevention of dirofilariasis.
The result is immediately visible
What does the researches says? Puppies and dogs participating in the clinical trials of the drug were 100% cured of helminthiasis (round and tapeworms) after the first administration of Supramil. This means that after a single use the drug helps to solve the problem of infection with internal parasites.
A new level of security
R-praziquantel is responsible for the increased safety of Supramil. Advanced technologies in the development of anthelmintic drugs have significantly improved the safety profile of Supramil compared to any traditional praziquantel-based anthelmintic product. The results of the studies demonstrate that the drug was safe for all animals participating in the experiment. Allergies, adverse effects on the body, and irritation were not registered. All animals are healthy and doing well. Supramil has a unique proprietary formulation.
Special flavoring benefits
A second, and the pill disappears in the mouth of a contented pet. Do you think this is a fairy tale? No, now this is reality. Supramil has impressive anthelmintic action and safety, as well as incredible eatability. You can easily give a small tablet in a special shell with a meat flavor to your pet, and he eats it on his own and without additional effort from the owner. Supramil, thanks for the taste! Now the pain of giving your pet an anthelmintic drug is a thing of the past.
Frequency of use
For puppies and dogs – once in 3 months. And also 10 days before vaccination and mating. To prevent dirofilariasis in puppies and dogs, the drug is given before the start of mosquito season regularly every 28-35 days. The drug is given for the last time in a month after the end of the mosquito season.
The principle of the action
The active components of the drug R-praziquantel and milbemycin oxime provide its wide spectrum of anthelmintic action.
Milbemycin oxime is a macrocyclic lactone obtained as a result of the enzymatic activity of Streptomyces hygroscopicus var. Aureolacrimosus, is active against larvae and imago of nematodes parasitizing in the gastrointestinal tract of cats, as well as larvae of the nematode Dirofilaria immitis.
The mechanism of action of milbemycin is due to an increase in the permeability of cell membranes for chloride ions (Cl-), which leads to overpolarization of the membranes of nerve and muscle tissue cells, paralysis and death of sensitive nematodes. The maximum plasma concentration of milbemycin oxime in cats is reached within 2 hours; bioavailability is about 80%. The compound is excreted from the body mainly unchanged.
R-praziquantel (levorotatory optical isomer) is a compound of the pyrazinisoquinoline group, its mechanism of action is based on inducing the decay of tegument, persistent depolarization of helminth muscle cells, disruption of energy metabolism, which causes paralysis and death of cestodes, and promotes their excretion from the gastrointestinal tract. R-praziquantel is rapidly absorbed in the gastrointestinal tract, reaching its maximum concentration in the blood plasma after 1-3 hours, reversibly binds to serum proteins (70-80%), partially metabolized in the liver, re-excreted into the intestine, excreted from the body mainly with urine (up to 80%) within 24 hours.
The use of active R-praziquantel in the composition of the preparation (instead of the racemic mixture of optical isomers of R-praziquantel and S praziquantel) made it possible to reduce the concentration of the compound while maintaining a high level of cestodicidal activity.
Supramil tablets are classified as low-hazard substances in terms of their impact on the body (hazard class 4 according to GOST 12.1.007); in recommended doses does not have a sensitizing, embryotoxic and teratogenic effect.
The drug is toxic to bees, as well as fish and other aquatic organisms.
Composition of the drug
R-praziquantel, milbemycin.
Contraindications
Contraindications to the use of Supramil tablets are the increased individual sensitivity of the animal to the components of the drug, including a history, severe renal and liver dysfunction.
Emaciated animals sick with infectious diseases, cats weighing less than 0.5 kg, kittens under 6 weeks old are not subject to deworming.
Drug form
Pills.
Period of validity
The shelf life of the medicinal product, subject to storage conditions in the manufacturer's sealed packaging, is 3 years from the date of production.
Do not use Supramil tablets beyond the expiration date.
Storage conditions
Store Supramil tablets in the manufacturer's sealed packaging, protected from light, separate from food and feed, at a temperature not exceeding 25 C.
Keep Supramil tablets out of the reach of children.
